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PostSubject: Print Maximize A new vaccine for nicotine addiction    Wed Jun 27, 2012 11:59 pm

A new vaccine for nicotine addiction



Researchers at Weill Cornell Medical College have developed and successfully tested in mice an innovative vaccine to treat nicotine addiction.

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In the journal Science Translational Medicine,the scientists describe how a single dose of their novel vaccine protects mice,over their lifetime,against nicotine addiction.The vaccine is designed to use the animals liver as a factory to continuously produce antibodies that gobble up nicotine the moment it enters the bloodstream,preventing the chemical from reaching the brain and even the heart.
As far as we can see,the best way to treat chronic nicotine addiction from smoking is to have these Pacman-like antibodies on patrol,clearing the blood as needed before nicotine can have any biological effect, says the studys lead investigator,Ronald Crystal.Our vaccine allows the body to make its own monoclonal antibodies against nicotine,and in that way,develop a workable immunity, Crystal says.Previously tested nicotine vaccines have failed in clinical trials because they all directly deliver nicotine antibodies,which only last a few weeks and require repeated,expensive injections,Crystal says.Plus,this kind of impractical,passive vaccine has had inconsistent results,perhaps because the dose needed may be different for each person,especially if they start smoking again,he adds.
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